Hydrochloric Acid → HCID 59496679, Verbindung

HRID 449368Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 449368
O.[OH-].[Li+].[NH2:4][C:5]1[N:10]=[C:9]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21]([NH:23][C@@H:24]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:25]([O:27]C)=[O:26])=[O:22])[CH2:18]3)=[CH:13][CH:12]=2)[CH:8]=[C:7]([N:36]2[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]2)[N:6]=1.Cl.[Li+].[Cl-]>CO.O.O1CCOCC1>[NH2:4][C:5]1[N:10]=[C:9]([C:11]2[CH:20]=[C:19]3[C:14]([CH2:15][CH2:16][N:17]([C:21]([NH:23][C@@H:24]([CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)[C:25]([OH:27])=[O:26])=[O:22])[CH2:18]3)=[CH:13][CH:12]=2)[CH:8]=[C:7]([N:36]2[CH2:37][CH2:38][N:39]([CH3:42])[CH2:40][CH2:41]2)[N:6]=1

Komponenten

8

Edukt 4

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 433294Lithium ChlorideHCID 86645777HCID 86645777, Verbindung

Produkt 1

HCID 59496679HCID 59496679, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Lithium hydroxide monohydrate (7.1 mg, 0.17 mmol) was added to a mixture of methyl (2S)-2-({[7-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}amino)-3-phenylpropanoate (30 mg, 0.057 mmol) in methanol (0.6 mL) and water (0.2 mL). The reaction mixture was stirred at r.t. overnight, and adjusted with 4N HCl in 1,4-dioxane to pH=5. The volatiles were removed under reduced pressure to afford the product which contaminated with LiCl and was directly used for next step reaction without further purification.

Aufarbeitung

  1. customThe volatiles were removed under reduced pressure
  2. customto afford the product which
  3. customwas directly used for next step reaction without further purification

Quellen und Nachweise

ORD-Eintrag
ord-15d594a2b4904990acfa57080da7aa59
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481732B2

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