Lamotrigine → 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

HRID 449792

Reaktionsgleichung

Reaktionsgleichung von HRID 449792
[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[Na+].[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20].[Na+]>CO>[CH:1]1[CH:6]=[C:5]([Cl:7])[C:4]([Cl:8])=[C:3]([C:9]2[N:14]=[N:13][C:12]([NH2:15])=[N:11][C:10]=2[NH2:16])[CH:2]=1.[C:18]([O-:26])(=[O:25])[CH:19]([CH2:21][C:22]([O-:24])=[O:23])[OH:20]

Komponenten

4

Edukt 2

HCID 3878LamotrigineHCID 8736Malic acid, disodium salt

Produkt 1

HCID 866323236-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxybutanedioate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

20 mg of lamotrigine was dissolved in 2 ml of methanol, 12 mg of malic acid sodium salt was added to the solution to form a single solution. The solution was then allowed to stand for several hours to effect the slow evaporation of solvent. The solids gathered were stored in screw cap vials for subsequent analysis.

Aufarbeitung

  1. customto form a single solution
  2. waitto stand for several hours
  3. customthe slow evaporation of solvent
  4. customcap vials for subsequent analysis

Quellen und Nachweise

ORD-Eintrag
ord-1bfa01b5902049028c09a97c1103eb66
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486927B2

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