1-Ethylpiperazine → 8-[1-(4-Ethylpiperazin-1-yl)dibenzothiophen-4-yl]-2-morpholin-4-ylchromen-4-one

HRID 45

Reaktionsgleichung

Reaktionsgleichung von HRID 45
CCN1CCNCC1.O=c1cc(N2CCOCC2)oc2c(-c3ccc(I)c4c3sc3ccccc34)cccc12>C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C(/C=C/c1ccccc1)/C=C/c1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd].[Pd]>CCN1CCN(c2ccc(-c3cccc4c(=O)cc(N5CCOCC5)oc34)c3sc4ccccc4c23)CC1

Komponenten

7

Edukt 2

HCID 791961-EthylpiperazineHCID 178418224HCID 178418224, Verbindung

Produkt 1

HCID 426443188-[1-(4-Ethylpiperazin-1-yl)dibenzothiophen-4-yl]-2-morpholin-4-ylchromen-4-oneAusbeute 0 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 10796Cesium carbonateReagenzHCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)KatalysatorHCID 9811564Bis(dibenzylideneacetone)palladiumKatalysatorHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

8-(1-iododibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one (20 mg, 0.04 mmol), 1-ethylpiperazine (9.42 µl, 0.07 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (2.145 mg, 3.71 µmol), TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM (0.849 mg, 0.93 µmol) and 2,3,4,6,7,8,9,10-octahydropyrimido[1,2-a]azepine (16.62 µl, 0.11 mmol) were suspended in dioxane (250 µl) and sealed into a microwave tube. The reaction was degased, purged with argon and heated to 130 °C over a period of 45 minutes in the microwave reactor. No reaction.

Quellen und Nachweise

ORD-Eintrag
ord-8dc05311ad5340e693477414d5741a5e
Quelldatensatz
750 AstraZeneca ELN dataset
Originallink
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