Diethyl Ether → 2-Bromo-1-(3-methylphenyl)ethan-1-one

HRID 450025

Reaktionsgleichung

Reaktionsgleichung von HRID 450025
[C:1]1([CH3:10])[CH:6]=[CH:5][CH:4]=[C:3]([C:7](=[O:9])[CH3:8])[CH:2]=1.[Br:11]Br.CCOCC>O1CCOCC1>[Br:11][CH2:8][C:7]([C:3]1[CH:2]=[C:1]([CH3:10])[CH:6]=[CH:5][CH:4]=1)=[O:9]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 114553-MethylacetophenoneHCID 24408Bromine

Produkt 1

HCID 100361292-Bromo-1-(3-methylphenyl)ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a solution of 1-m-tolyl-ethanone (6.0 g, 44.72 mmol) in dioxane (5 ml), bromine (7.14 g, 44.72 mmol) in dioxane (10 ml) and ether (15 ml) was added and stirred at room temperature for 5 hr. The reaction mixture was poured into ice water and the compound was extracted using ethyl acetate. The organic layer was washed with water and brine, dried over anhydrous sodium sulfate, filtered and then evaporated to give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%). The crude compound obtained was used in the next step without further purification.

Aufarbeitung

  1. extractionthe compound was extracted
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customto give crude 2-bromo-1-m-tolyl-ethanone, 7.6 g (80%)

Quellen und Nachweise

ORD-Eintrag
ord-0586c48dda1c4b35beae4608fb38fbc0
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

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