5-Nitro-1H-indole-2-carboxylic acid propylamide → HCID 62057141, Verbindung

HRID 450720

Reaktionsgleichung

Reaktionsgleichung von HRID 450720
[CH2:1]([NH:4][C:5]([C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([N+:16]([O-])=O)=[CH:11][CH:10]=2)=[O:6])[CH2:2][CH3:3]>CCO.[Pd]>[CH2:1]([NH:4][C:5]([C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][C:12]([NH2:16])=[CH:11][CH:10]=2)=[O:6])[CH2:2][CH3:3]

Komponenten

4

Edukt 1

HCID 670239755-Nitro-1H-indole-2-carboxylic acid propylamide

Produkt 1

HCID 62057141HCID 62057141, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel2×

Versuchsvorschrift

To a solution of 5-nitro-1H-indole-2-carboxylic acid propylamide (2.94 g, 11.9 mmol) in EtOH (150 ml) a suspension of palladium on charcoal (10%, 1 g) in EtOH was added. The mixture was hydrogenated at atmospheric pressure. After filtration and removal of the solvents in vacuo the product was obtained as a yellow powder (2.46 mg, 95%).

Aufarbeitung

  1. additionwas added
  2. filtrationAfter filtration and removal of the solvents in vacuo the product

Quellen und Nachweise

ORD-Eintrag
ord-630127751cc1404dbcd018eddda7be57
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486984B2

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