Acetic Acid → HCID 178476642, Verbindung

HRID 45299

Reaktionsgleichung

Reaktionsgleichung von HRID 45299
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[C:11]([OH:14])(=[O:13])[CH3:12].[OH-].[Na+]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:11]([O-:14])(=[O:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 14219Metformin HydrochlorideHCID 14798Sodium Hydroxide

Produkt 1

HCID 178476642HCID 178476642, VerbindungAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
30 °C

Versuchsvorschrift

20.0 g (1 equivalent) of metformin hydrochloride and 30 Ml of water, and then 10 Ml (1.45 equivalents) of acetic acid were added to a reactor, and stirred for 2 hours at 30° C. to dissolve thoroughly. Then 1.23 g (1.5 equivalents) of aqueous solution of sodium hydroxide was added to the reaction solution. The resulting crystal was filtered and washed with acetone, and then dried at 60° C. to obtain 16.7 g of metformin acetate (yield: 73.0%).

Aufarbeitung

  1. dissolutionto dissolve thoroughly
  2. filtrationThe resulting crystal was filtered
  3. washwashed with acetone
  4. customdried at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-6fb44aec1ba6457d8f8eea270e485c9a
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

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