Acetic Acid → HCID 178476642, Verbindung

HRID 45302

Reaktionsgleichung

Reaktionsgleichung von HRID 45302
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].C(O)(C)C.[C:14]([OH:17])(=[O:16])[CH3:15]>O>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:14]([O-:17])(=[O:16])[CH3:15]

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 3776IsopropanolHCID 178484382HCID 178484382, Verbindung

Produkt 1

HCID 178476642HCID 178476642, VerbindungAusbeute 47,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

78 g (1 equivalent) of metformin free base, 234 Ml of isopropanol, 234 Ml of water and 57 Ml (1.65 equivalents) of acetic acid were added to a reactor, and stirred. The resulting crystal was filtered and washed with isopropanol, and then dried at 60° C. to obtain 54.6 g of metformin acetate (yield: 47.8%).

Aufarbeitung

  1. filtrationThe resulting crystal was filtered
  2. washwashed with isopropanol
  3. customdried at 60° C.

Quellen und Nachweise

ORD-Eintrag
ord-cd5a98c6f5d745438361e4b8efe6e631
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541474B2

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