Water → HCID 178527393, Verbindung

HRID 456681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 456681
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]([C:17]3[C:18](Cl)=[N:19][CH:20]=[CH:21][CH:22]=3)=O)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.O.[NH2:27][NH2:28].O>C(O)C>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]([CH2:6][S:7]([C:10]2[CH:11]=[C:12]([C:15]3[C:17]4[C:18](=[N:19][CH:20]=[CH:21][CH:22]=4)[NH:28][N:27]=3)[NH:13][CH:14]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 18436879{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone

Produkt 1

HCID 178527393HCID 178527393, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

{4-[(4-chlorobenzyl)sulfonyl]-1H-pyrrol-2-yl}(2-chloropyridin-3-yl)methanone (280 mg, 0.711 mmol) and 359 mg of hydrazine monohydrate (7.11 mmol) were mixed in 4 mL of ethanol. The mixture was stirred at 80° C. overnight (16 hour) and then cooled down to room temperature. Water was added and filtered. Washed with additional water and methanol to collect the product, dried to afford 250 mg (95% yield) of the title compound.

Aufarbeitung

  1. temperaturecooled down to room temperature
  2. filtrationfiltered
  3. washWashed with additional water and methanol
  4. customto collect the product
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b4cd261dd8044ae3a7e767a86bf535b7
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07186716B2

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