Water → 2,5-Difluoro-4-(pyrrol-1-yl)benzoic acid

HRID 4569Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4569
[F:1][C:2]1[CH:10]=[C:9]([NH2:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CO[C:15]1(OC)[CH2:19][CH2:18][CH2:17]O1.O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:19][CH:18]=[CH:17]2)[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 3

HCID 962WaterHCID 11788317DimethoxytetrahydrofuraneHCID 201514774-Amino-2,5-difluorobenzoic acid

Produkt 1

HCID 201514742,5-Difluoro-4-(pyrrol-1-yl)benzoic acidAusbeute 79,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

5.2 grams (0.03 mol) of 2,5-difluoro-4-aminobenzoic acid, melting at 250°-3°, are dissolved in 60 ml of glacial acetic acid, and 4 grams (0.03 mol) of dimethoxytetrahydrofuran are added. The mixture is heated at the boil for 10 minutes, 20 ml of water are added and the resulting mixture is left to cool. The precipitate formed is filtered off and washed with water to give 5.3 grams of a solid melting at 196°-8° C.

Aufarbeitung

  1. temperatureThe mixture is heated at the boil for 10 minutes
  2. waitthe resulting mixture is left
  3. temperatureto cool
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-dc223d62d465498286c60c57753211e7
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727080

Notizen zur Reaktion

Wird geladen…