Guanidine Hydrochloride → 4-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine

HRID 457875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 457875
CN(C)[CH:3]=[C:4]([C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.[NH2:20][C:21]([NH2:23])=[NH:22].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)=[CH:3][N:20]=[C:21]([NH2:23])[N:22]=1

Komponenten

6

Edukt 3

HCID 5742Guanidine HydrochlorideHCID 11430Potassium CarbonateHCID 670738543-(Dimethylamino)-1-(furan-2-yl)-2-(pyridin-4-yl)prop-2-en-1-one

Produkt 1

HCID 97947204-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amineAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A suspension of 3-(dimethylamino)-1-(2-furyl)-2-(4-pyridyl)-2-propene-1-one (2.2 g, 9.08 mmol), guanidine hydrochloride (2.6 g, 27.2 mmol) and potassium carbonate (7.5 g, 54.3 mmol) in N,N-dimethylformamide (20 mL) was stirred at 70° C. for 12 hours. After cooling as it was, the reaction mixture was diluted with water. The resulting crystals were collected by filtration and washed with water, to give the title compound (1.73 g, 80%) as a pale yellow solid.

Aufarbeitung

  1. temperatureAfter cooling as it
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-6d8106a2920646acb514d843bfc9b85c
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07189717B2

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