Tetrahydrofuran → HCID 22637025, Verbindung

HRID 459841

Reaktionsgleichung

Reaktionsgleichung von HRID 459841
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4](Cl)[CH:3]=1.C([Li])CCC.CCCCCC.[B:22]([O:27]C)([O:25]C)[O:23]C.C1C[O:32][CH2:31]C1>>[CH3:31][O:32][C:4]1[CH:3]=[C:2]([O:27][B:22]([OH:23])[OH:25])[CH:7]=[CH:6][C:5]=1[O:8][CH3:9]

Komponenten

5

Edukt 4

HCID 8028TetrahydrofuranHCID 8470Trimethyl borateHCID 30165374-Bromo-2-chloroanisoleHCID 178418244HCID 178418244, Verbindung

Produkt 1

HCID 22637025HCID 22637025, Verbindung

Versuchsvorschrift

To a THF solution of 4-bromo-2-chloroanisole was added an n-butyllithium/n-hexane solution at −78° C., followed by 30 minutes of stirring. Then, trimethyl borate was added and the whole was warmed to room temperature, followed by 30 minutes of stirring. Using the residue obtained by evaporation of the solvent instead of 3,4-dimethoxyphenylboric acid, an objective compound was obtained in a similar manner to Reference Example 1.

Aufarbeitung

  1. waitfollowed by 30 minutes
  2. stirringof stirring

Quellen und Nachweise

ORD-Eintrag
ord-1115ae46fc4c4112a137d8b25c599060
Quelldatensatz
uspto-grants-2007_03
Patentnummer
US07196080B2

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