Ethanol → (2,4-Dimethylthiophen-3-yl)methanol

HRID 460978Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 460978
[BH4-].[Na+].[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH:9]=[O:10].C(O)C>O>[CH3:3][C:4]1[S:5][CH:6]=[C:7]([CH3:11])[C:8]=1[CH2:9][OH:10]

Komponenten

5

Edukt 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 111477702,4-Dimethylthiophene-3-carbaldehyde

Produkt 1

HCID 12875266(2,4-Dimethylthiophen-3-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

0.68 G. (18 mmol) of sodium borohydride was added in three portions to a solution of 10.08 g. (72 mmol) of 2,4-dimethylthiophene-3-carboxaldehyde in 120 ml. of ethanol. After 15 min., the reaction mixture was poured into water, extracted with ether, dried and the solvent evaporated. The resulting residue was recrystallized from hexane to yield 2,4-dimethyl-3-hydroxymethylthiophene, m.p. 80°-81° C.

Aufarbeitung

  1. extractionextracted with ether
  2. customdried
  3. customthe solvent evaporated
  4. customThe resulting residue was recrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-789808508e4648deaddf676c40b55dd7
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04061656

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