Water → 2,7-Bis[4-(3-azabicyclo[3.2.2]nonan-3-yl)butyryl]fluorene

HRID 461963

Reaktionsgleichung

Reaktionsgleichung von HRID 461963
Cl[CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:19]=[CH:18][C:17]2[C:16]3[C:11](=[CH:12][C:13]([C:20](=[O:25])[CH2:21][CH2:22][CH2:23]Cl)=[CH:14][CH:15]=3)[CH2:10][C:9]=2[CH:8]=1)=[O:6].[CH:26]12[CH2:34][CH2:33][CH:30]([CH2:31][CH2:32]1)[CH2:29][NH:28][CH2:27]2.[I-].[K+].O>CC(=O)CC>[CH:26]12[CH2:34][CH2:33][CH:30]([CH2:31][CH2:32]1)[CH2:29][N:28]([CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:19]=[CH:18][C:17]3[C:16]4[C:11](=[CH:12][C:13]([C:20](=[O:25])[CH2:21][CH2:22][CH2:23][N:28]5[CH2:29][CH:30]6[CH2:33][CH2:34][CH:26]([CH2:32][CH2:31]6)[CH2:27]5)=[CH:14][CH:15]=4)[CH2:10][C:9]=3[CH:8]=1)=[O:6])[CH2:27]2

Komponenten

6

Edukt 4

HCID 962WaterHCID 4875Potassium IodideHCID 92403-Azabicyclo[3.2.2]nonaneHCID 131705491,1'-(9H-Fluorene-2,7-diyl)bis(4-chlorobutan-1-one)

Produkt 1

HCID 213929692,7-Bis[4-(3-azabicyclo[3.2.2]nonan-3-yl)butyryl]fluorene

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6569Methyl Ethyl KetoneLösungsmittel

Versuchsvorschrift

A mixture of 11.25g (0.03 mole) of 2,7-bis(4-chlorobutyryl)fluorene, 30.1g (0.24 mole) of 3-azabicyclo[3.2.2]nonane and 10.0g (0.06 mole) of potassium iodide in 200 ml butanone is heated at reflux with stirring for 3 days. The reaction mixture was poured into 1000 ml of water, and the resulting solid precipitate filtered and recrystallized from chloroform-acetone to yield the desired product.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux
  3. filtrationthe resulting solid precipitate filtered
  4. customrecrystallized from chloroform-acetone

Quellen und Nachweise

ORD-Eintrag
ord-8473c2850e8a4a778bc52f25ae3b2d26
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04064347

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