Acetic Anhydride → Nitric Acid

HRID 462129

Reaktionsgleichung

Reaktionsgleichung von HRID 462129
C1O[C@@H]2[C@@H]([O:9][N+:10]([O-:12])=[O:11])CO[C@@H]2[C@@H]1O.C1O[C@@H]2[C@@H](O)CO[C@@H]2[C@@H]1O.[C:24]([O:27][C:28](=[O:30])[CH3:29])(=[O:26])[CH3:25]>>[N+:10]([O-:12])([OH:11])=[O:9].[C:24]([O:27][C:28](=[O:30])[CH3:29])(=[O:26])[CH3:25]

Komponenten

5

Edukt 3

HCID 7918Acetic AnhydrideHCID 12597IsosorbideHCID 62989Isosorbide 2-mononitrate

Produkt 2

HCID 944Nitric AcidHCID 7918Acetic Anhydride

Versuchsvorschrift

The following process for preparing 1,4:3,6-dianhydro-D-glucitol 2-nitrate is described: acylating 1,4:3,6-dianhydro-D-glucitol with 0.5 to 1.5 molar equivalents of acetic anhydride in the presence of an acid catalyst, nitrating the product so obtained with a mixture of nitric acid and acetic anhydride, hydrolyzing the product so obtained in the presence of an inorganic base and isolating 1,4:3,6-dianhydro-D-glucitol 2-nitrate. The 1,4:3,6-dianhydro-D-glucitol 2-nitrate is useful as a coronary vasodilator.

Quellen und Nachweise

ORD-Eintrag
ord-7f6d1bd3a7d64f5cabbc56f6cd46a244
Quelldatensatz
uspto-grants-1977_12
Patentnummer
US04065488

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