1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 46217

Reaktionsgleichung

Reaktionsgleichung von HRID 46217
[Br:1]Br.[OH:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[CH:6][C:5]=1[C:14]([OH:16])=[O:15]>C(O)(=O)C>[Br:1][C:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]([OH:3])=[C:5]([C:14]([OH:16])=[O:15])[CH:6]=1

Komponenten

4

Edukt 2

HCID 68441-Hydroxy-2-naphthoic acid2×HCID 24408Bromine

Produkt 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acidAusbeute 92,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Bromine (6.1 mL, 120 mmol) was added to a solution of 1-hydroxy-2-naphthoic acid (compound 66, 18.9 g, 100 mmol) in glacial acetic acid (250 mL). The mixture was stirred at room temperature overnight. The resulting solid was filtered and dried in vacuo to yield the title compound (24.6 g, 92%) as a white solid.

Aufarbeitung

  1. filtrationThe resulting solid was filtered
  2. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-50e18a4d23c74d9490e3660b81c779fe
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541380B2

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