Sodium Hydroxide → 3-(1-Ethyl-1-methylpropyl)-5-isoxazolamine

HRID 462353

Reaktionsgleichung

Reaktionsgleichung von HRID 462353
[C:1]([CH2:3][C:4]([C:6]([CH2:10][CH3:11])([CH3:9])[CH2:7][CH3:8])=O)#[N:2].Cl.[NH2:13][OH:14].[OH-].[Na+]>O>[NH2:2][C:1]1[O:14][N:13]=[C:4]([C:6]([CH2:10][CH3:11])([CH3:9])[CH2:7][CH3:8])[CH:3]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 159096Hexanenitrile, 4-ethyl-4-methyl-3-oxo-HCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 924023-(1-Ethyl-1-methylpropyl)-5-isoxazolamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A 16.5 Kg portion of methyl 2-ethylbutyrate was reacted with 60 Kg of n-butyl lithium, diisopropylamine, and 19.1 Kg of methyl iodide to provide 17.4 Kg of methyl 2-ethyl-2-methylbutyrate. A 7.5 Kg portion of the ester thus formed was reacted with 3.25 Kg of acetonitrile and 5.03 g of sodium hydride in 33 liters of tetrahydrofuran to provide 1-ethyl-1-methylpropyl cyanomethyl ketone. The ketone thus formed was reacted with 4.35 Kg of hydroxylamine hydrochloride and 2.54 Kg of sodium hydroxide in 44 liters of water to provide 5.65 Kg of 5-amino-3-(1-ethyl-1-methylpropyl)isoxazole.

Quellen und Nachweise

ORD-Eintrag
ord-bca35372dd5044f29426392106e218d7
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04515625

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