Reaktionsgleichung
[CH3:1][N:2]([CH3:30])[CH2:3][CH2:4][CH2:5][N:6]([C:21]1[C:26]([N+:27]([O-])=O)=[CH:25][CH:24]=[CH:23][N:22]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14].[OH-].[Na+]>C(O)C.O.[Zn]>[CH3:30][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][N:6]([C:21]1[C:26]([NH2:27])=[CH:25][CH:24]=[CH:23][N:22]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:14]Komponenten
6
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 3
Versuchsvorschrift
A mixture of (0.05 mole) [2-[[3-(dimethylamino)propyl](3-nitro-2-pyridinyl)amino]phenyl]phenylmethanone, 13 g, (0.20 mole) of zinc dust, 2 g (0.05 mole) of sodium hydroxide in 75 ml ethanol and 25 ml water is stirred under reflux for 1 hr. The mixture is filtered and evaporated under reduced pressure. The residue is dissolved in methylene chloride and the resulting solution is dried over magnesium sulfate and decolorized with charcoal and filtered. The filtrate is evaporated to dryness and to give the title compound in crude mixture.
Aufarbeitung
- temperatureunder reflux for 1 hr
- filtrationThe mixture is filtered
- customevaporated under reduced pressure
- dissolutionThe residue is dissolved in methylene chloride
- dry with materialthe resulting solution is dried over magnesium sulfate
- filtrationfiltered
- customThe filtrate is evaporated to dryness
Quellen und Nachweise
- ORD-Eintrag
- ord-84544717d0a64aa1b8919cc724576681
- Quelldatensatz
- uspto-grants-1985_05
- Patentnummer
- US04518603
Verknüpfte Notizen
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