4-Hydroxybenzoic Acid → 4-(4-Hydroxybutoxy)benzoic acid

HRID 463595

Reaktionsgleichung

Reaktionsgleichung von HRID 463595
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[OH-].[Na+].C([O:16][CH2:17][CH2:18][CH2:19][CH2:20]Br)(=O)C.Cl>O>[OH:16][CH2:17][CH2:18][CH2:19][CH2:20][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 1354-Hydroxybenzoic AcidHCID 313Hydrochloric AcidHCID 14798Sodium Hydroxide3×HCID 784911-Butanol, 4-bromo-, 1-acetate

Produkt 1

HCID 152185964-(4-Hydroxybutoxy)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

In a 22 liter stirred reactor, 1.16 kilograms of p-hydroxy-benzoic acid (M.W. 138) in 4 liters of water are neutralized by the addition of 0.5 liter of 40% aqueous sodium hydroxide. The temperature is adjusted to 50° C. and over a period of one hour, 1200 milliliters of 4-bromobutyl acetate are slowly added. The temperature is then raised to 90° C.+10° C. and the hot reaction mixture kept at pH 10 by continuous titration with a 40% sodium hydroxide solution. When no change in pH is noted for a period of 45 minutes the reaction is considered complete, an additional liter of water is then added, and sufficient 40% sodium hydroxide solution to raise the pH to 11. While still hot, concentrated hydrochloric acid is added in large enough quantities to lower the pH to 1.2. The mixture is allowed to cool overnight while stirring and the precipitate collected on a filter. The precipitate is then thoroughly washed with water to remove excess acid until the wash has attained a pH of at least 5. The precipitate is then dried and dissolved in hot methanol (15% solution), and the solution filtered to remove any insolubles (usually about 6-7%). While the clear methanol solution is still hot, hot water is added to adjust the solvent ratio to 10:1 methanol/water, and set aside to let the product crystallize out overnight yielding p-(4-hydroxy-n-butoxy)benzoic acid having a melting point of 146°-148° C.

Aufarbeitung

  1. waitWhen no change in pH is noted for a period of 45 minutes
  2. temperatureto cool overnight
  3. stirringwhile stirring
  4. customthe precipitate collected on a filter
  5. washThe precipitate is then thoroughly washed with water
  6. customto remove excess acid until the wash
  7. customThe precipitate is then dried
  8. dissolutiondissolved in hot methanol (15% solution)
  9. filtrationthe solution filtered
  10. customto remove any insolubles (usually about 6-7%)
  11. additionhot water is added
  12. customcrystallize out overnight

Quellen und Nachweise

ORD-Eintrag
ord-4fdc29d5b37b4153a989f8cf3c46e386
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04543952

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