Bromine → Carbamic acid, [3-(bromoacetyl)phenyl]-, ethyl ester

HRID 464695Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464695
[Br:1]Br.[C:3]([C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])[CH:9]=[CH:10][CH:11]=1)(=[O:5])[CH3:4]>O1CCOCC1.CCOCC>[Br:1][CH2:4][C:3]([C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:17])[O:14][CH2:15][CH3:16])[CH:9]=[CH:10][CH:11]=1)=[O:5]

Komponenten

5

Edukt 2

HCID 24408BromineHCID 717681ethyl N-(3-acetylphenyl)carbamate

Produkt 1

HCID 20216369Carbamic acid, [3-(bromoacetyl)phenyl]-, ethyl esterAusbeute 97,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

24.1 gm of bromine were added slowly over a period of 30 minutes to a stirred suspension of 28.5 gm of ethyl N-(3-acetyl-phenyl)-carbamate in 13.3 gm of dry dioxane and 245 ml of dry ether. After stirring the reaction solution for 2 hours more, it was cooled, and the product which crystallized out was collected and washed with ether, yielding 38.5 gm of the title compound, m.p. 108°-110° C.

Aufarbeitung

  1. temperatureit was cooled
  2. customthe product which crystallized out
  3. customwas collected
  4. washwashed with ether

Quellen und Nachweise

ORD-Eintrag
ord-866038e8074e44b6821a3f01a76dc7fd
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04548944

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