3-Hydroxybenzaldehyde → 3-[(3-Methylpiperidin-1-yl)methyl]phenol

HRID 4648

Reaktionsgleichung

Reaktionsgleichung von HRID 4648
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][NH:13][CH2:12]1.C(O)=O.N>O>[CH3:10][CH:11]1[CH2:16][CH2:15][CH2:14][N:13]([CH2:5][C:4]2[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=2)[CH2:12]1

Komponenten

6

Edukt 4

HCID 1013-HydroxybenzaldehydeHCID 222AmmoniaHCID 284Formic AcidHCID 790813-Methylpiperidine

Produkt 1

HCID 133646663-[(3-Methylpiperidin-1-yl)methyl]phenol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

24.4 g (0.2 mol) of 3-hydroxybenzaldehyde are mixed with 40 ml (about 0.4 mol) of 3-methylpiperidine and 20 ml (about 0.52 mol) of 100% formic acid with cooling and then stirred for 2 hours at 120° C. When the reaction mixture has cooled to room temperature, it is poured into water and rendered alkaline with ammonia, and the precipitated solid is filtered off and recrystallised from ethanol.

Aufarbeitung

  1. temperaturewith cooling
  2. temperatureWhen the reaction mixture has cooled to room temperature
  3. filtrationthe precipitated solid is filtered off
  4. customrecrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-e9c53b21b5524c4296badbb52530d5b3
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727081

Verknüpfte Notizen

Wird geladen…