Water → 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

HRID 46503Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 46503
[O:1]1[CH:11]2[CH:2]1[CH2:3][C:4]1[C:9]([CH2:10]2)=[CH:8][CH:7]=[CH:6][CH:5]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Li].O>CCOCC>[OH:1][CH:11]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=2)[CH2:2]1

Komponenten

5

Edukt 3

HCID 962WaterHCID 108880512,3-Epoxy-1,2,3,4-tetrahydronaphthaleneHCID 178506720HCID 178506720, Verbindung

Produkt 1

HCID 203873802-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
-20 °C

Versuchsvorschrift

A solution of 25 g of 2,3-epoxy-1,2,3,4-tetrahydronaphthalene in 250 ml ether is added to a solution of 2-pyridyl lithium (prepared from 2-bromopyridine and butyllithium) cooled to -20° C. After addition, the mixture is allowed to come to room temperature over several hours, then cooled again and treated with water. The separated, dried organics are taken to dryness, and the product purified by chromatography in neutral alumina.

Aufarbeitung

  1. additionAfter addition
  2. waitto come to room temperature over several hours
  3. temperaturecooled again
  4. customthe product purified by chromatography in neutral alumina

Quellen und Nachweise

ORD-Eintrag
ord-e020e1f78509438189a408ee230a55d1
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04173640

Notizen zur Reaktion

Wird geladen…