2-(Morpholinomethyl)-pyridine → 4-((Piperidin-2-yl)methyl)morpholine

HRID 465050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465050
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.[Pt](=O)=O>[N:1]1([CH2:7][CH:8]2[CH2:13][CH2:12][CH2:11][CH2:10][NH:9]2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Komponenten

5

Edukt 2

HCID 2696942-(Morpholinomethyl)-pyridineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 31633954-((Piperidin-2-yl)methyl)morpholineAusbeute 52,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

First, 2-[(4-morpholinyl)methyl]pyridine (94.0 g, 0.53 mol) is dissolved in glacial acetic acid (600 ml) and hydrogenated in the presence of platinum(IV) oxide (10.0 g) as catalyst for 2 hours at a hydrogen pressure of 3 bar and a temperature of 50° C. After cooling, the catalyst is filtered off, the filtrate is freed from solvent and the residue is distilled in vacuo. The desired compound (51.0 g) is obtained in the form of a colorless liquid, boiling point 4 mm Hg 91°-92° C.

Aufarbeitung

  1. customa temperature of 50° C
  2. temperatureAfter cooling
  3. filtrationthe catalyst is filtered off
  4. distillationthe residue is distilled in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6c56b257a38d47f38fb5eebc01b1ff4f
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04550107

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