Butyl bromide → 2,3-Dichloro-4-methoxy-N-n-butylaniline

HRID 466591

Reaktionsgleichung

Reaktionsgleichung von HRID 466591
[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])O.[Na+]>COCCO>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:12][CH2:13][CH2:14][CH3:15]

Komponenten

5

Edukt 3

HCID 8002Butyl bromideHCID 516892Sodium BicarbonateHCID 136906392,3-Dichloro-4-methoxyaniline

Produkt 1

HCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80192-MethoxyethanolLösungsmittel

Versuchsvorschrift

A mixture of 2,3-dichloro-4-methoxyaniline (19.2 g), n-butylbromide (22.0 g), sodium hydrogen carbonate (40 g) and methylcellosolve (350 ml) is stirred at 95°-100° C. for about 48 hours. The cooled mixture is filtered, and the filtrate is evaporated in vacuo. The remaining material is washed with water and is thereafter recrystallized from ethanol to give the title compound with a melting point of 47°-49° C.

Aufarbeitung

  1. filtrationThe cooled mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. washThe remaining material is washed with water
  4. customis thereafter recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-8fb866fbda2a421cb6d9f91b2097482b
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157039

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