Acetic Acid → S-Ethyl-L-cysteine

HRID 468039

Reaktionsgleichung

Reaktionsgleichung von HRID 468039
Cl.[NH2:2][C@H:3]([C:6]([OH:8])=[O:7])[CH2:4][SH:5].[CH2:9](Br)[CH3:10].O.N.C(O)(=O)C>O>[CH2:9]([S:5][CH2:4][C@@H:3]([C:6]([OH:8])=[O:7])[NH2:2])[CH3:10]

Komponenten

6

Edukt 4

HCID 176Acetic AcidHCID 6332Ethyl BromideHCID 60960Cysteine HydrochlorideHCID 12896473Azane;hydrate

Produkt 1

HCID 92185S-Ethyl-L-cysteine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

SEC is synthesized from L-cysteine hydrochloride (1.58 g, 0.01 mol) and ethyl bromide (1.09 g, 0.01 mol) with the following steps. The reaction mixture is diluted with water in a titration manner until a clear solution is formed. No more than necessary amount of water should be added to further dilute the mixture. Ammonia water was added to PH 9.5-10 with stirring at room temperature. After 2 hours reaction, the mixture is acidified with acetic acid to PH 5-5.5. The desired product was cooled in the refrigerator, filtered and washed successively with water and ethyl ether. The chemical structure of SEC is determined by Proton Nuclear Magnetic Resonance Spectroscopy.

Aufarbeitung

  1. customis formed
  2. additionto further dilute the mixture
  3. customAfter 2 hours reaction

Quellen und Nachweise

ORD-Eintrag
ord-5bc938180df9479d8bd30e80dc1a8e4b
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623919B2

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