Water → HCID 59625812, Verbindung

HRID 468176Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 468176
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:20](OC)(OC)OC.O>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[N:1]=[CH:20]2)=[CH:14][CH:15]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 9005Trimethyl orthoformateHCID 59625705HCID 59625705, Verbindung

Produkt 1

HCID 59625812HCID 59625812, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 60d (0.18 g, 0.693 mmol) and trimethyl orthoformate (0.7 mL, 6.39 mmol) in DMF (2 mL) was refluxed for 5 h and then cooled to room temperature. Water was added to the mixture. The resulting solid was filtered, washed, with water, and dried. The crude product 60e was used in the next reaction without purification. MS m/z (M+H+) 271.1.

Aufarbeitung

  1. temperaturewas refluxed for 5 h
  2. filtrationThe resulting solid was filtered
  3. washwashed, with water
  4. customdried
  5. customThe crude product 60e was used in the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-ec903683ba134bdda9a8b40ab9d0df8b
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623858B2

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