4-[2-(Pyrrolidin-1-yl)ethyl]piperidine → Ammonia

HRID 469132

Reaktionsgleichung

Reaktionsgleichung von HRID 469132
[CH:1]1([N:4]([CH2:18][C:19]2[S:23][C:22]([C:24](OCC)=[O:25])=[N:21][N:20]=2)[S:5]([C:8]2[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=2[CH3:17])(=[O:7])=[O:6])[CH2:3][CH2:2]1.[N:29]1([CH2:34][CH2:35][CH:36]2[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]2)[CH2:33][CH2:32][CH2:31][CH2:30]1.C[Al](C)C>ClCCCl>[NH3:4].[CH:1]1([N:4]([CH2:18][C:19]2[S:23][C:22]([C:24]([N:39]3[CH2:38][CH2:37][CH:36]([CH2:35][CH2:34][N:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)[CH2:41][CH2:40]3)=[O:25])=[N:21][N:20]=2)[S:5]([C:8]2[C:13]([CH3:14])=[CH:12][C:11]([O:15][CH3:16])=[CH:10][C:9]=2[CH3:17])(=[O:7])=[O:6])[CH2:3][CH2:2]1

Komponenten

6

Edukt 3

HCID 2962934-[2-(Pyrrolidin-1-yl)ethyl]piperidineHCID 16682925TrimethylaluminumHCID 58393201ethyl 5-({Cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate

Produkt 2

HCID 222AmmoniaHCID 58393259HCID 58393259, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 111,2-DichloroethaneLösungsmittel

Versuchsvorschrift

The title compound was prepared according to general procedure AT using ethyl 5-({cyclopropyl[(4-methoxy-2,6-dimethylphenyl)sulfonyl]amino}methyl)-1,3,4-thiadiazole-2-carboxylate (30 mg, 0.07 mmol), 4-[2-(pyrrolidin-1-yl)ethyl]piperidine (29 mg, 0.16 mmol) and trimethylaluminium (2 M in toluene, 0.07 mL) in DCE (5 mL). The crude product was purified using FCC, eluting with 95:4.5:0.5 DCM:MeOH:NH3, to afford the title compound.

Aufarbeitung

  1. customThe title compound was prepared
  2. customThe crude product was purified
  3. washeluting with 95:4.5:0.5 DCM

Quellen und Nachweise

ORD-Eintrag
ord-94aee724d7084f98928d3daa8e337184
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623859B2

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