Hydrochloric Acid → 2-Cyclobutylthiazole-4-carboxylic acid

HRID 471120

Reaktionsgleichung

Reaktionsgleichung von HRID 471120
O.[OH-].[Li+].[CH:4]1([C:8]2[S:9][CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)[CH2:7][CH2:6][CH2:5]1.Cl>C1COCC1.O>[CH:4]1([C:8]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[CH2:5][CH2:6][CH2:7]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 54513950Ethyl 2-cyclobutylthiazole-4-carboxylate

Produkt 1

HCID 200843232-Cyclobutylthiazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Lithium hydroxide monohydrate (0.38 g) was added to a solution of ethyl 2-cyclobutylthiazole-4-carboxylate (example 58, step b) (0.48 g) in a mixture of THF (8 mL) and water (2 mL). The resulting suspension was stirred overnight at RT. The reaction was acidified with aqueous HCl solution (2M, 5 mL) and evaporated to dryness. The residue was partitioned between brine (5 mL) and ethyl acetate (20 mL). The layers were separated and the aqueous phase extracted with ethyl acetate (2×20 mL). The combined organic solutions were dried over sodium sulphate, filtered and evaporated to give the subtitled compound as a white solid. Yield 0.38 g.

Aufarbeitung

  1. customevaporated to dryness
  2. customThe residue was partitioned between brine (5 mL) and ethyl acetate (20 mL)
  3. customThe layers were separated
  4. extractionthe aqueous phase extracted with ethyl acetate (2×20 mL)
  5. dry with materialThe combined organic solutions were dried over sodium sulphate
  6. filtrationfiltered
  7. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-429f5daeeaab4e7cab08a06e928ae83c
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629271B2

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