Formic Acid → Ethyl 3-(4-cyanophenyl)propanoate

Pd/C (0.6 g, 10%, 50% water wet) was added to a solution of ethyl (2E)-3-(4-cyanophenyl)-2-propenoate (2.7 g, 13.42 mmol) in ethyl acetate (40 mL) under an argon atmosphere. It was mixed with TEA (3.74 mL, 26.8 mmol) and formic acid (2.57 mL, 67.1 mmol). The reaction mixture was refluxed at 90° C. under argon for 1 h. It was filtered through a Celite pad. The filtrate was then washed with water, 5% NaHCO3 solution and brine, dried over Na2SO4, and concentrated to provide the title compound as a pale yellow oil (2.65 g, 97% yield). LCMS: rt=2.94 min, [M+H+]=204.0

1. filtrationIt was filtered through a Celite pad
2. washThe filtrate was then washed with water, 5% NaHCO3 solution and brine
3. dry with materialdried over Na2SO4
4. concentrationconcentrated

ORD-Eintrag

ord-b5a9fa8d91214e19bd0e6d2ad5301a0e

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08637536B2