959-24-0 → Sotalol

HRID 479264

Reaktionsgleichung

Reaktionsgleichung von HRID 479264
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:3].Cl>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:18])[C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:11][CH:12]=1)[CH3:1]

Komponenten

3

Edukt 1

HCID 66245959-24-0

Produkt 1

HCID 5253Sotalol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel2×

Versuchsvorschrift

Polyvinylpyrrolidone (500 g) is dissolved in about 25 kg water (or a mixture of water and alcohol) and 10 kg of sotalol hydrochloride is mixed therein to provide a sotalol/binder solution. In a fluidized bed coater, 10 kg of sugar spheres (20 to 50 mesh) are suspended in warm air and spray coated with the sotalol/binder solution until the seeds are uniformly coated with a desired amount of sotalol.

Aufarbeitung

  1. additionis mixed

Quellen und Nachweise

ORD-Eintrag
ord-a5e86ecfad164324903f52277f64ff44
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06645524B2

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