3,4,5-Trimethoxybenzoic Acid → 2-Bromo-3,4,5-trimethoxybenzoic acid

HRID 48085

Reaktionsgleichung

Reaktionsgleichung von HRID 48085
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[C:8]([OH:10])=[O:9]>C(O)(=O)C>[Br:1][C:11]1[C:12]([O:16][CH3:17])=[C:13]([O:14][CH3:15])[C:5]([O:4][CH3:3])=[CH:6][C:7]=1[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 2

HCID 83573,4,5-Trimethoxybenzoic AcidHCID 24408Bromine

Produkt 1

HCID 3130972-Bromo-3,4,5-trimethoxybenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel2×

Versuchsvorschrift

A solution of bromine (100 mmol) in 100 mL of acetic acid is added dropwise to a solution of 3,4,5-trimethoxybenzoic acid (100 mmol) in 100 mL of acetic acid cooled by an ice water bath. After the red color of the resulting mixture is discharged, the mixture is poured onto 500 g of crushed ice. The resulting solid is collected by filtration, dried over P2O5 in vacuo, and recrystallized from Et2O to give the product as a pale yellow solid.

Aufarbeitung

  1. temperaturecooled by an ice water bath
  2. filtrationThe resulting solid is collected by filtration
  3. dry with materialdried over P2O5 in vacuo
  4. customrecrystallized from Et2O

Quellen und Nachweise

ORD-Eintrag
ord-b83e621f8de54011ba0a2acf013a775e
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06702705B1

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