Aniline → Methyl 3-anilino-5-bromobenzoate
Reaktionsgleichung
COC(=O)c1cc(Br)cc(Br)c1.Nc1ccccc1>CC(=O)O.CC(=O)O.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.Cc1ccccc1.O=C([O-])[O-].[Cs+].[Cs+].[Pd]>COC(=O)c1cc(Br)cc(Nc2ccccc2)c1Komponenten
7
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 4
Reaktionsbedingungen
- Temperatur
- 110 °C
Versuchsvorschrift
aniline (0.380 g, 4.08 mmol), methyl 3,5-dibromobenzoate (1.000 g, 3.40 mmol), Pd(OAc)2 (0.076 g, 0.34 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.295 g, 0.51 mmol) and CESIUM CARBONATE (1.663 g, 5.10 mmol) were stirred in toluene (10 mL) and degassed with nitrogen for 15 minutes. The mixture was then heated at 110 °C under nitrogen for 24 hours. No evidence of any significant amount of product (ester or acid) therfore abandaned.
Quellen und Nachweise
- ORD-Eintrag
- ord-c6d710180f5249588ab02dc546a2ae67
- Quelldatensatz
- 750 AstraZeneca ELN dataset
- Originallink
- Quelle ansehen
Notizen zur Reaktion
Wird geladen…
