Potassium Dichromate → 3'-METHOXY-3-PHENYLPROPIOPHENONE

HRID 481162Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 481162
[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:20]([OH:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1>O.S(=O)(=O)(O)O.CCOCC>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:20](=[O:29])[CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[CH:18][CH:19]=1

Komponenten

6

Edukt 2

HCID 24502Potassium DichromateHCID 15524231HCID 15524231, Verbindung

Produkt 1

HCID 112071953'-METHOXY-3-PHENYLPROPIOPHENONEAusbeute 83,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 962WaterLösungsmittelHCID 1118Sulfuric AcidLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
20 °C

Versuchsvorschrift

14.9 g (0.05 mole) of potassium dichromate in a mixture of 50 ml of water and 10 ml of concentrated sulfuric acid were added to a solution of 34 g (0.14 mole) of 1-(3-methoxyphenyl)-3-phenylpropan-1-ol in 500 ml of ether while cooling with ice and stirred overnight at 20° C. The aqueous, green phase was separated and extracted twice with 100 ml of ether each time. The combined ether extracts were dried over sodium sulfate and the solvent was then removed in vacuo. 28.0 g (83%) of the compound 1-(methoxyphenyl)-3-phenylpropan-1-one were obtained as a yellow oil, which was reacted further without prior purification.

Aufarbeitung

  1. temperaturewhile cooling with ice
  2. customThe aqueous, green phase was separated
  3. extractionextracted twice with 100 ml of ether each time
  4. dry with materialThe combined ether extracts were dried over sodium sulfate
  5. customthe solvent was then removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-592d635826f04e7fb005ac5fb930fe88
Quelldatensatz
uspto-grants-2003_11
Patentnummer
US06653508B2

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