Water → 2-(3-Hydroxy-5-methyl-phenyl)-isoindole-1,3-dione

HRID 482252Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 482252
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:10]1(=O)[O:15][C:13](=[O:14])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12.O>C(O)(=O)C>[OH:9][C:4]1[CH:3]=[C:2]([N:1]2[C:13](=[O:14])[C:12]3[C:11](=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:10]2=[O:15])[CH:7]=[C:6]([CH3:8])[CH:5]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 6811Phthalic AnhydrideHCID 30186673-Amino-5-methylphenol

Produkt 1

HCID 189450002-(3-Hydroxy-5-methyl-phenyl)-isoindole-1,3-dioneAusbeute 80,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

36.0 g (292 mmol) 3-amino-5-methylphenol and 73.5 g (496 mmol) phthalic acid anhydride were heated for 2 h to boiling under reflux in 280 ml glacial acetic acid. Water was added, it was heated for a short time, allowed to cool and filtered. 59.6 g (80%) 2-(3-hydroxy-5-methyl-phenyl)-isoindole-1,3-dione of Fp 174°-175° C. was obtained.

Aufarbeitung

  1. temperatureit was heated for a short time
  2. temperatureto cool
  3. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-8a1b06fd11ca42558641f7b5f6be1dc6
Quelldatensatz
uspto-grants-1998_08
Patentnummer
US05795892

Notizen zur Reaktion

Wird geladen…