[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester → HCID 20633122, Verbindung

HRID 48234Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 48234
C([O:3][C:4](=O)[C:5]([N:7]([CH2:21][CH2:22][CH2:23][CH3:24])[C:8]1[C:17]([N+:18]([O-])=O)=[CH:16][CH:15]=[C:14]2[C:9]=1[CH2:10][CH2:11][CH2:12][NH:13]2)=[O:6])C>C(O)(=O)C.[Pd]>[CH2:21]([N:7]1[C:8]2[C:9]3[CH2:10][CH2:11][CH2:12][NH:13][C:14]=3[CH:15]=[CH:16][C:17]=2[NH:18][C:4](=[O:3])[C:5]1=[O:6])[CH2:22][CH2:23][CH3:24]

Komponenten

4

Edukt 1

HCID 53663592[Butyl(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)-amino]oxo-acetic Acid Ethyl Ester

Produkt 1

HCID 20633122HCID 20633122, VerbindungAusbeute 71 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of the product from Example 88 (0.63 g) in 75 mL of acetic acid was treated with 56 Pd/C (0.2 g) and shaken on a Parr apparatus under a hydrogen atmosphere (52 psi) for 12 hours. The catalyst was removed by filtration and the filtrate evaporated. The residue was washed with ether to give the title compound (0.35 g, 71% yield).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated
  3. washThe residue was washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-7ef201be0f5a416b828d947e63f1f096
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06703391B2

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