Glyceric acid → Solketal

Reaktionsgleichung

[OH:1][CH:2]([CH2:6][OH:7])[C:3]([OH:5])=O.CO[C:10](OC)([CH3:12])[CH3:11].C(O)[C@H](O)C(O)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:11][C:10]1([CH3:12])[O:1][CH:2]([CH2:3][OH:5])[CH2:6][O:7]1

Komponenten

Edukt 4

HCID 752Glyceric acid

HCID 64952,2-Dimethoxypropane

HCID 6326776L-Glyceric acid

HCID 21226445Aluminium lithium hydride

Produkt 1

HCID 7528Solketal

Versuchsvorschrift

Alternatively, the 2,3-dihydroxypropanoic acid (D- or L-glyceric acid) is reacted with 2,2-dimethoxypropane without lower alcohol present to prepare 2,3-O-isopropylidene D- or L-glyceric acid which is then reacted with lithium aluminum hydride to produce the solketal.

Quellen und Nachweise

ORD-Eintrag: ord-2a265e764ef74be3891a82215fae5017
Quelldatensatz: uspto-grants-1986_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04575558

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