Sodium Iodide → Ethyl 4-iodo-3-oxobutanoate

HRID 488068Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 488068
[I-:1].[Na+].Cl[CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]>CC(C)=O.CCCCC.O.C(OCC)(=O)C>[I:1][CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]

Komponenten

7

Edukt 2

HCID 5238Sodium Iodide2×HCID 69484Ethyl 4-chloroacetoacetate

Produkt 1

HCID 12779728Ethyl 4-iodo-3-oxobutanoate

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 180AcetoneLösungsmittelHCID 962WaterLösungsmittelHCID 8003PentaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Sodium iodide (228 g) was dissolved in acetone (135 mL) and cooled to 0° C. 4-chloro-3-oxobutanoic acid, ethyl ester (5.0 g) was added to the sodium iodide solution and the mixture was stirred at 0° C. for 20 minutes It was diluted with pentane (135 mL) and water (135 mL). The reaction mixture was diluted with ethyl acetate and washed with water, brine and dried over anhydrous sodium sulfate to give an intermediate (4-Iodo-3-oxobutanoic acid, ethyl ester; 6.2 g yield).

Aufarbeitung

  1. washwashed with water, brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customto give

Quellen und Nachweise

ORD-Eintrag
ord-504ebb95dd7b44b89bba276575829643
Quelldatensatz
uspto-grants-1994_03
Patentnummer
US05298625

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