Water → 3-(3-Chlorophenoxy)nitrobenzene

To a stirred solution of potassium t-butoxide (12.3 g) in DMSO (100 mL) was added at once 3-chlorophenol (12.86 g). The resulting solution was stirred for 5 minutes at room temperature, then 3-fluoronitrobenzene (12.70 g) was added all at once. The resulting dark mixture was heated at 120° C. for 12 hours, cooled to room temperature then poured into water (700 mL). The resulting mixture was extracted with ether (2×200 mL). The organic fraction was washed with 2N NaOH (100 mL), then with water (100 mL). After drying (MgSO4), the solvent was evaporated and the resulting dark oil was distilled to give 3-(3-chlorophenoxy)nitrobenzene as a yellow oil, b.p. 135-140° C. at 0.05 mm.

1. temperatureThe resulting dark mixture was heated at 120° C. for 12 hours
2. temperaturecooled to room temperature
3. extractionThe resulting mixture was extracted with ether (2×200 mL)
4. washThe organic fraction was washed with 2N NaOH (100 mL)
5. dry with materialAfter drying (MgSO4)
6. customthe solvent was evaporated
7. distillationthe resulting dark oil was distilled

ORD-Eintrag

ord-89cc7c7040e5453ca0c9c3c22b33282b

Quelldatensatz

uspto-grants-2004_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06706740B2