Tetrahydrofuran → 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrate

HRID 495010Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 495010
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.O1CCCC1.[C:42]([OH:51])(=[O:50])[C@@H:43]([C@H:45]([C:47]([OH:49])=[O:48])[OH:46])[OH:44]>C(OCC)C>[C:47]([C@@H:45]([C@H:43]([C:42]([OH:51])=[O:50])[OH:44])[OH:46])([OH:49])=[O:48].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 8028Tetrahydrofuran2×HCID 444305L-Tartaric acidHCID 11677552E-2110 free base

Produkt 1

HCID 866016071-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrateAusbeute 84,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (100 mg) was dissolved in a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml). Thereafter, a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml) containing L-(+)-tartaric acid (31 mg) was added to the reaction solution at room temperature. The deposited solid was collected by filtration, and the obtained product was then washed with diethyl ether, so as to obtain the subject compound (110 mg).

Aufarbeitung

  1. additionwas added to the reaction solution at room temperature
  2. filtrationThe deposited solid was collected by filtration
  3. washthe obtained product was then washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-6da6a0d92e6849b8bdd44d6806ab5369
Quelldatensatz
uspto-grants-2009_05
Patentnummer
US07538123B2

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