Formic Acid → 4-Methylbenzimidazole
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9].Cl.[OH-].[NH4+].[CH:13](O)=O>>[CH3:9][C:3]1[C:2]2[N:1]=[CH:13][NH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1Komponenten
5
Versuchsvorschrift
To a flask were added 2.0 g 2,3-diaminotoluene, 1.0 g 90% formic acid and 30 ml 5M hydrochloric acid and the mixture was heated to 90 C under nitrogen for 4 hours. After cooling to 22 C, the mixture was basified with aqueous ammonium hydroxide and the product was removed by filtration and washed with water. The product was purified by column chromatography using pure ethyl acetate resulting in 1.0 g brown solid.
Aufarbeitung
- temperaturethe mixture was heated to 90 C under nitrogen for 4 hours
- temperatureAfter cooling to 22 C
- customthe product was removed by filtration
- washwashed with water
- customThe product was purified by column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-bca620d033864315bf0ee9387fe50dbd
- Quelldatensatz
- uspto-grants-2009_05
- Patentnummer
- US07538931B2
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