Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate → Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamate

HRID 495627

Reaktionsgleichung

Reaktionsgleichung von HRID 495627
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:21])[F:20])=[CH:17][C:16]([N+:23]([O-])=O)=[CH:15][C:14]=2[N+:26]([O-])=O)[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:4][CH:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]([C:13]2[C:18]([C:19]([F:22])([F:20])[F:21])=[CH:17][C:16]([NH2:23])=[CH:15][C:14]=2[NH2:26])[C:8](=[O:12])[O:9][CH2:10][CH3:11])=[CH:29][CH:30]=1

Komponenten

4

Edukt 1

HCID 20827746Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate

Produkt 1

HCID 20827745Ethyl 4-chlorobenzyl[2,4-diamino-6-(trifluoromethyl)phenyl]carbamateAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Ethyl 4-chlorobenzyl[2,4-dinitro-6-(trifluoromethyl)phenyl]carbamate (294.7 mg) was dissolved in ethyl acetate (20 ml), and to the solution was added 10% Pd—C (267.7 mg). The reaction mixture was stirred under hydrogen atmosphere for 7 hours. The catalyst was filtered, and washed with ethyl acetate. The filtrate was concentrated in vacuo to give the title compound (248.7 mg).

Aufarbeitung

  1. filtrationThe catalyst was filtered
  2. washwashed with ethyl acetate
  3. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-22e9506486f448879edec20695904024
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06939887B2

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