Water → HCID 86759852, Verbindung

HRID 497726

Reaktionsgleichung

Reaktionsgleichung von HRID 497726
Cl[C:2]1[C:3]2[S:20][C:19]([NH2:21])=[N:18][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=2[F:17])[N:7]=1.[NH2:22][CH2:23][C@H:24](O)[CH3:25].[OH2:27]>CN1CCCC1=O.CCN(C(C)C)C(C)C>[NH2:21][C:19]1[S:20][C:3]2[C:2]([NH:22][CH:23]([OH:27])[CH2:24][CH3:25])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=3[F:17])=[N:5][C:4]=2[N:18]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 439938(2R)-1-aminopropan-2-olHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

Produkt 1

HCID 86759852HCID 86759852, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 13387N-methyl-2-pyrrolidoneLösungsmittelHCID 81531DiisopropylethylamineLösungsmittel

Versuchsvorschrift

The product from example 1, step (b) (70.0 g) and (R)-1-amino-propan-2-ol (32 ml) in N-methylpyrrolidinone (600 ml) and Hunigs base (71 ml) was heated at 110° C. for 16 hours. The mixture was poured into water (5 L) and the crude product collected at by filtration. This solid was purified by recrystallisation from acetonitrile (2.5 L) to give 65 g of the subtitled compound.

Aufarbeitung

  1. filtrationthe crude product collected at by filtration
  2. customThis solid was purified by recrystallisation from acetonitrile (2.5 L)

Quellen und Nachweise

ORD-Eintrag
ord-1c6fd978249740a2a653eae94ca91aa6
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949643B2

Verknüpfte Notizen

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