Ethyl Acetate → HCID 178429193, Verbindung

HRID 497957

Reaktionsgleichung

Reaktionsgleichung von HRID 497957
[CH3:1][C:2]1[CH:6]=[C:5]([NH2:7])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1.[C:14](OCC)(=[O:19])[CH2:15][C:16]([CH3:18])=O.C(OCC)(=O)C>C(O)(=O)C>[CH3:1][C:2]1[C:6]2[C:5](=[N:7][C:14]([OH:19])=[CH:15][C:16]=2[CH3:18])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[N:3]=1

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 8868Ethyl AcetoacetateHCID 7351323-Methyl-1-(pyridin-2-yl)-1H-pyrazol-5-amine

Produkt 1

HCID 178429193HCID 178429193, VerbindungAusbeute 63,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of 3-methyl-1-(2-pyridinyl)-1H-pyrazol-5-amine (5.1 g, 29 mmol) and ethyl acetoacetate (3.8 g, 30 mmol) in acetic acid (14 mL) was stirred at 100° C. for 4 hours. The solution was cooled to room temperature and ethyl acetate was added thereto. The resulting crude crystals were collected by filtration, and recrystallized from ethanol to give the title compound (4.4 g, 62% yield).

Aufarbeitung

  1. filtrationThe resulting crude crystals were collected by filtration
  2. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-7f85c5375b614450a81179d53aaa42b7
Quelldatensatz
uspto-grants-2005_09
Patentnummer
US06949648B2

Verknüpfte Notizen

Wird geladen…