Tetrahydrofuran → 6-(Methylthio)nicotinonitrile

HRID 499418Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 499418
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]#[N:9])=[CH:4][N:3]=1.[CH3:10][S-:11].[Na+].C1COCC1.C(OCC)(=O)C>O>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([S:11][CH3:10])=[N:3][CH:4]=1)#[N:9]

Komponenten

6

Edukt 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 4378561Sodium methanethiolateHCID 51520946-Chloro-3-pyridinecarbonitrile

Produkt 1

HCID 229395276-(Methylthio)nicotinonitrileAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

2-Chloro-5-cyanopyridine (2.10 g, 15.1 mmol) and sodium thiomethoxide (1.16 g, 16.5 mmol) were added to THF (30 ml). The reaction mixture was refluxed for 9 hrs and combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (2.26 g, 100%) as pale yellow crystals.

Aufarbeitung

  1. temperatureThe reaction mixture was refluxed for 9 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-87a4d9ad0796450d925b4650bea98971
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07767665B2

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