Water → 4-(4-Cyanophenyl)butyl methanesulfonate

HRID 500473Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 500473
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[OH:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:18]=[CH:17][C:14]([C:15]#[N:16])=[CH:13][CH:12]=1.C(N(CC)CC)C.O>ClCCl>[CH3:1][S:2]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]#[N:16])=[CH:17][CH:18]=1)(=[O:4])=[O:3]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 185403804-(4-Hydroxybutyl)benzonitrile

Produkt 1

HCID 185404244-(4-Cyanophenyl)butyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

Methanesulfonyl chloride (2.32 mL, 30 in mmol) was added to a cooled (0° C.), stirred solution of 4-(4-hydroxybutyl)benzonitrile (from step (ii) above, 5.2 g, 29.7 mmol) and triethylamine (4.35 mL) in dichloromethane (50 mL). The resulting, mixture was stirred for 4 h before water (150 mL) was added, and the organic layer separated, dried and concentrated to give the sub-title compound. This product was used directly in the next step without further purification.

Aufarbeitung

  1. additionwas added
  2. customthe organic layer separated
  3. customdried
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-73951895fb8043c9807dfd3d8a437746
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772229B2

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