Sodium Hydroxide → HCID 22024679, Verbindung

HRID 501007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 501007
[N:1]1[CH:6]=[CH:5][C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=1.[Br:13]Br.[OH-].[Na+]>C(O)(=O)C>[Br:13][C:5]1[C:4]([NH:7][CH:8]([CH2:11][CH3:12])[CH2:9][OH:10])=[N:3][CH:2]=[N:1][CH:6]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 24408BromineHCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

Produkt 1

HCID 22024679HCID 22024679, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

2-(4-Pyrimidinylamino)-1-butanol (4.2 g) was dissolved in acetic acid (42 mL), and bromine (1.5 mL) was added dropwise at a normal temperature. After stirred for 1 day at the same temperature, the solution was neutralized with a 5N aqueous sodium hydroxide solution and extracted with ethyl acetate, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1) to give the title compound (4.4 g) as white crystals.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. customthe solvent was evaporated
  3. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:n-hexane=1.1)

Quellen und Nachweise

ORD-Eintrag
ord-ce9896d298fa4e62bba5fbfba8c67826
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772249B2

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