Ethanol → 2-Methyl-2-(2-thienyl)propanohydrazide

HRID 502947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 502947
O.[NH2:2][NH2:3].C(O)C.[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9](OCC)=[O:10].C(OCC)(=O)C>O>[CH3:7][C:8]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)([CH3:14])[C:9]([NH:2][NH2:3])=[O:10]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 8857Ethyl AcetateHCID 24654Hydrazine hydrate (1:1)HCID 21099804Ethyl 2-methyl-2-(thiophen-2-yl)propanoate

Produkt 1

HCID 684672282-Methyl-2-(2-thienyl)propanohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

Hydrazine monohydrate (2.6 ml) was added to an ethanol (10 ml) solution of ethyl 2-methyl-2-(2-thienyl)propanoate (530 mg), followed by stirring at 70° C. for 48 hours. After the reaction solution and ethyl acetate were added to water, the organic layer was separated. Furthermore, the organic layer washed with saturated brine and, after drying over anhydrous sodium sulfate and filtration, the solvent was removed by evaporation under reduced pressure to obtain 447 mg of 2-methyl-2-(2-thienyl)propanohydrazide (colorless oil).

Aufarbeitung

  1. customthe organic layer was separated
  2. washFurthermore, the organic layer washed with saturated brine
  3. dry with materialafter drying over anhydrous sodium sulfate and filtration
  4. customthe solvent was removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f2d9600b8fef4ae08d1d12d2e70eb7b7
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776897B2

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