Water → 3-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid

HRID 503158Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 503158
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH3:20])=[C:14]([C:17]#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[OH2:21].S(=O)(=O)(O)[OH:23]>C(O)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH3:20])=[C:14]([C:17]([OH:23])=[O:21])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 962Water2×HCID 1118Sulfuric AcidHCID 222607803-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile

Produkt 1

HCID 222609563-(3-Fluoro-phenyl)-6-methoxy-1H-indazole-5-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A total of 172 mg of 3-(3-fluoro-phenyl)-6-methoxy-1H-indazole-5-carbonitrile obtained in Production Example II-1-d was dissolved in 2 ml of acetic acid, 0.7 ml of water and 0.5 ml of sulfuric acid, followed by stirring at 110° C. for 18 hours. After cooling to room temperature, water was added to the reaction mixture. The resulting crystals were washed with water, to give 159 mg of the title compound as light pink crystals.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. washThe resulting crystals were washed with water

Quellen und Nachweise

ORD-Eintrag
ord-c4f5ede5238741fd85045d91540c0195
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07776890B2

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