Lithium hydroxide, monohydrate → Lithium 2-amino-6-chloronicotinate

HRID 505068Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 505068
O[Li:2].O.[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8]>O.CO>[NH2:4][C:5]1[N:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:6]=1[C:7]([O-:9])=[O:8].[Li+:2]

Komponenten

5

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 57415887Methyl 2-amino-6-chloronicotinate

Produkt 1

HCID 59772570Lithium 2-amino-6-chloronicotinateAusbeute 114,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A solution of LiOH.H2O (1.38 g, 33 mmol) in water (33 mL) was added in one portion to a suspension of methyl 2-amino-6-chloronicotinate (6.08 g, 27 mmol) in MeOH (110 mL). The reaction mixture was stirred at 70° C. for 24 hours, and gradually became homogeneous. The solvents were removed under reduced pressure, and after the resulting white solid was dried under vacuum (<1 mmHg) to constant weight, 5.51 g (95%) of lithium 2-amino-6-chloronicotinate was obtained.

Aufarbeitung

  1. customThe solvents were removed under reduced pressure
  2. customafter the resulting white solid was dried under vacuum (<1 mmHg) to constant weight

Quellen und Nachweise

ORD-Eintrag
ord-abc11101d7ea4bea821c01a30c9631ae
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781437B2

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