Hydrochloric Acid → 4-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

HRID 505697Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 505697
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1.O.[NH2:14][NH2:15].C(O)C.[ClH:19]>CO.C(OCC)C>[ClH:19].[NH:14]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1)[NH2:15]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 594293094-Fluoro-2-(methoxymethyl)benzonitrile

Produkt 1

HCID 469151914-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 4-fluoro-2-(methoxymethyl)benzonitrile (110 mg, 0.67 mmol), hydrazine monohydrate (133 mg, 0.13 mL, 2.6 mmol) and ethanol (5 mL) was heated to reflux overnight. The mixture was cooled to room temp and condensed. The residue was dissolved in methanol and treated with 2.0 N Hydrogen chloride in diethyl ether. The solvent was removed and the solid was dried to give 4-hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride as an off-white solid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customcondensed
  4. customThe solvent was removed
  5. customthe solid was dried

Quellen und Nachweise

ORD-Eintrag
ord-6b1498ae6dcc4bf6858cdda7915a81dd
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07781428B2

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