Water → 2-Bromo-4,5-dimethoxybenzoic acid

HRID 508389

Reaktionsgleichung

Reaktionsgleichung von HRID 508389
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([OH:8])=[O:7].[Br:14]Br.O>Cl>[Br:14][C:9]1[CH:10]=[C:11]([O:12][CH3:13])[C:3]([O:2][CH3:1])=[CH:4][C:5]=1[C:6]([OH:8])=[O:7]

Komponenten

5

Edukt 3

HCID 962WaterHCID 7121Veratric AcidHCID 24408Bromine

Produkt 1

HCID 2229632-Bromo-4,5-dimethoxybenzoic acidAusbeute 96,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

3,4-Dimethoxybenzoic acid (25.0 g) was suspended in concentrated hydrochloric acid (35%) (500 mL), and bromine (23.0 g, 1.05 equivalents) was added dropwise to the resultant suspension at 25° C. Subsequently, the resultant mixture was stirred for seven hours. Water (500 mL) was added to the mixture, and the mixture was stirred for one hour. Thereafter, the precipitated crystals were filtrated, and then dried under reduced pressure, to thereby produce crude crystals of 2-bromo-4,5-dimethoxybenzoic acid (34.47 g) (yield: 96.2%).

Aufarbeitung

  1. filtrationThereafter, the precipitated crystals were filtrated
  2. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ab2cb0c75bab4d10a547cd259bedac49
Quelldatensatz
uspto-grants-2015_08
Patentnummer
US09096511B2

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